Disputas cand.med Dagny Førde

Avhandlingen er tilgjengelig her

The doctoral thesis

Auditoriet er åpent for publikum, men disputasen vil også bli strømmet her 

Opptak av disputasen vil være tilgjengelig i et døgn.

The auditorium is open to the public. The defense will still be streamed here

A recording of the disputation will be available for 24 hours

Prøveforelesning over oppgitt emne holdes kl. 09.15, samme sted

Prøveforelesningen vil også bli strømmet her/the trial lecture will be streamed:

"Immunterapi ved lungekreft: historikk, dagens status og fremtidsutsikter"

Populærvitenskapelig sammendrag av avhandlingen:

Lung cancer is the leading cause for cancer-related deaths worldwide, accounting for roughly one in five cancer deaths. This PhD project analyzed certain biomarkers in tumor tissue for predicting survival, to understand more of who is at higher risk and who may need closer follow-up, additional or more tailored treatment.
We analyzed tumor samples from a large group of patients from Northern Norway who had non-small cell lung cancer (the most common type) removed by surgery. Using special laboratory staining techniques, we made small RNA molecules and immune cells visible in the tissue. We then used digital microscopy and machine-learning software to count these biomarkers. The counts of biomarkers were then analyzed together with survival data from the patients.
The RNA markers (miR-17-5p and miR-20a-5p) showed mixed results, suggesting they are not reliable on their own. In contrast, certain “fighter” T cells (CD8 cells with the TCF1 marker) were associated with better outcomes. Another CD8 subset (CD57+ cells) may also be relevant, but all markers need further validation before routine clinical use.

Hovedveileder

Professor Sigve Andersen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bi-veileder:

Professor Tom Dønnem, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Førsteamanuensis Thomas Kilvær, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Bedømmelseskomité

Professor Simon Ekman, Karolinska Institutet, Sverige – 1. opponent

Førsteamanuensis Maria Ramnefjell, Universitetet i Bergen – 2. opponent

Førsteamanuensis Vegard Brun, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Professor Rasmus Goll, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet