Disputas- Samantha Xavier

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: Arterial and venous thrombosis; shared origins or separate diseases? Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed her. Disputasen starter kl. 1215. Auditoriet er åpent for publikum, men vil også bli strømmet her. Opptak av disputasen vil være tilgjengelig i et døgn. The auditorium is open to the public. The defense will still be streamed here. A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism is a life-threatening condition caused by blood clots. P-selectin, a protein involved in inflammation and clotting, is found in plasma both in a soluble form and on the surface of extracellular vesicles (EVs). This thesis investigated whether P-selectin could improve DVT diagnosis or predict incident VTE and recurrence.
In patients with suspected DVT, EV-bound P-selectin showed no diagnostic value, and soluble P-selectin performed only moderately and failed to improve the current diagnostic algorithm. In a population-based study, higher P-selectin levels were associated with an increased risk of future VTE in women but not in men. In another population-based study on patients who already had VTE, P-selectin levels did not predict recurrence. These findings underscore the difficulty of identifying superior biomarkers for VTE and provide critical directions for future research into sex-specific risk factors.

Hovedveileder
Førsteamanuensis Omri Snir, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet. 

Bi-veiledere
Professor John Bjarne Hansen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Professor Sigrid Brækkan, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Casper Ullsten-Wahlund, Vinnova. 

Bedømmelseskomité
Professor Håkon Reikvam, Universitetet i Bergen - 1. opponent.
Lektor, ph.d.  Inger Lise Gade, Aalborg University Hospital - 2. opponent. 
Professor Jorunn Pauline Cavanagh, Institutt for klinisk medisin, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Førsteamanuensis Åsa Birna Birgisdottir, Institutt for klinisk medisin, UiT Norges arktiske universitet.