Disputas - Master of Science in Mathematics Arya Panthalanickal Vijayakumar

Avhandlingen

The doctoral thesis

Auditoriet er åpent for publikum, men disputasen vil likevel bli strømmet

Opptak av disputasen vil være tilgjengelig i et døgn

The auditorium is open to the public, but the defense wil also be streamed

A recording of the defense will be available for 24 hours

Prøveforelesning over oppgitt emne holdes kl. 10:15, samme sted

"What should be required of a new risk marker before it is used in cardiovascular disease prevention?"

Prøveforelesningen vil også bli strømmet/the trial lecture will also be streamed

Populærvitenskapelig sammendrag av avhandlingen

Our hearts do not all age at the same speed. Researchers have developed a way to measure the age of heart by using an electrocardiogram (ECG) and an artificial intelligence algorithm. In this PhD, standard ECG tests from thousands of participants in the Tromsø Study were analysed with artificial intelligence to estimate each person’s “heart age”. By comparing heart age with real age, I studied whether people with less education or long-term patterns of high blood pressure, cholesterol and obesity have an older heart, and whether this predicts heart attack, stroke and early death. if this algorithm remain robust against algorithmic or data changes. The results show that an older-looking heart is linked to higher risk, and that social and lifestyle factors throughout life may speed up heart ageing. And based on the available 3 models (with algorithmic and data changes) the heart age agree well indicating the model’s reliability. This knowledge can help target prevention earlier, robustly and more fairly.

Hovedveileder

Olena Lakuchukova, UiO

Biveileder

Professor Tom Wilsgaard, ISM

Bedømmelseskomité

Professor Johan Sundström, Uppsala University – 1. opponent

Ph.d. Mari Nordbø Gynnild, NTNU, UiO - 2. opponent

Professor Tiina Ikäheimo, Institutt for samfunnsmedisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité

Disputasleder

Forsker Jonas Johansson,  Institutt for samfunnsmedisin , Det helsevitenskapelige fakultet, UiT Norges arktiske universitet