Hege Lynum Pedersen
Job description
Førsteamanuensis på RNA og molekylær patologi forskningsgruppe
Studieprogramleder for master i biomedisin
Jeg er utdannet sivilingeniør i bioteknologi og har en ph.d. i molekylærbiologi. Jeg jobber hovedsaklig innenfor immunologi og autoimmunitet, men er også interessert i immuncellers påvirkning på kreftutvikling.
Susannah von,
Kristin Andreassen,
Hege Lynum
:
Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
Aud-Malin Karlsson,
Saba,
Charlotte G,
Premasany,
Valentina,
Francesca
et al.:
Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease
Kristin Andreassen,
Hege Lynum
:
Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
Luz P,
Eduardo,
Shuichiro,
Mingzeng,
Hege Lynum,
Xinghao
et al.:
Modulation of the itaconate pathway attenuates murine lupus
Arthritis & Rheumatology 2022 DOI
Luz P.,
Hege Lynum,
Xinghao,
Yaima L.,
Nickie,
Carmelo
et al.:
Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone
Arthritis & Rheumatology 2020 DOI
Seyed Esmaeil,
Premasany,
Aud-Malin Karlsson,
Mikael Ryan,
Kjersti Daae,
anita
et al.:
Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
Kristel,
Hege Lynum,
Ingar
:
Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
X,
Luz P.,
Carmelo,
S,
Hege Lynum,
ZX
et al.:
Gasdermin D modulates murine lupus and its associated organ damage
Arthritis & Rheumatology 2020 DOI
S,
S,
Luz P.,
LJ,
G,
RR
et al.:
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2020 DOI
KA,
Luz P.,
I,
N,
PC,
DL
et al.:
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
Hege Lynum,
Kjersti Daae,
Dhivya,
Gudrun,
Natalya,
Gabriella
et al.:
Lupus nephritis: low urinary DNase I levels reflect loss of
renal DNase I and may be utilized as a biomarker of
disease progression
Dhivya,
Hege Lynum,
Natalya,
Kjersti Daae,
Lorena,
Ramon
et al.:
IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
Kjersti Daae,
Hege Lynum,
Silje,
Dhivya,
Andrea,
Ole Petter
et al.:
Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
Ole Petter,
Dhivya,
Hege Lynum,
Kjersti Daae,
Natalya
:
Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
American Journal of Pathology 2016 DOI
Hege Lynum,
Kenneth,
Colin,
Ingar,
Elin
:
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
Hege Lynum,
Kjersti Daae,
Dhivya,
Natalya,
Ole Petter
:
Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
Seminars in Nephrology 2015 DOI
Adele Kim,
Hege Lynum
:
Recombinant expression and purification of an ATP-dependent DNA ligase from Aliivibrio salmonicida
Protein Expression and Purification 2014 DOI
Rafi,
Geir Åsmund,
Hilde,
Erik,
hege lynum,
steinar
et al.:
Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida
Journal of Molecular Microbiology and Biotechnology 28. diciembre 2012 DOI
hege lynum,
erik,
steinar,
Hilde,
Lotte,
Sunniva Katharina
et al.:
Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
Marine Genomics 2010 DOI
hege lynum,
Rafi,
EK,
Hanna-Kirsti S.,
Stefan,
S
et al.:
Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
Journal of Microbiology 2010 DOI
hege lynum,
Nils Peder,
Ingar
:
The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida
Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009 DOI
Aud-Malin Karlsson,
Premasany,
Thea Ekrem,
anita,
Stine,
Susannah von
et al.:
Early imiquimod-induced onset of disease in lupus-prone NZBW-F1 mice
2025
Thea,
Aud-Malin Karlsson,
Premasany,
Anita,
Charlotte,
Stine
et al.:
IL-18 deficiency does not affect development of renal tertiary lymphoid structures in imiquimod induced SLE
Lupus Science and Medicine 2022 DOI
Kristin Andreassen,
Hege Lynum
:
Characterising tertiary lymphoid structures in lupus-prone mice
Research Features Magazine 05. mayo 2021 DOI
Hege Lynum,
Luz P.,
Xinghao,
Vance,
Mariana J.
:
White blood cell metabolism in human SLE
2019
Luz P.,
Hege Lynum,
Yaima L.,
Nickie,
Carmelo,
Yudong
et al.:
The coenzyme Q10 analog idebenone ameliorates murine lupus
2019
Hege Lynum,
Kjersti Daae,
Dhivya,
Gudrun,
Natalya,
Gabriella
et al.:
LUPUS NEPHRITIS: SEVERELY REDUCED URINARY DNASE I LEVELS REFLECT LOSS OF RENAL DNASE I, DISEASE PROGRESSION AND MAY REDUCE THE NEED FOR RENAL BIOPSIES
2018
Hege Lynum
:
Lupus nefritt i mus og mennesker - hva har vi lært, og er det muligheter for terapi?
Revmatologi BestPractice 2016
Hege Lynum
:
MARZymes - Marine enzymes from the Arctic region
2013
Adele Kim,
Bjørn,
Marcin Miroslaw,
Gro Elin Kjæreng,
hege lynum,
Concetta De
et al.:
Hot Investigations into Cold-Sourced Enzymes
2013
hege lynum,
Bjørn,
Erik,
Adele Kim,
Marcin Miroslaw,
Gro Elin Kjæreng
et al.:
Genome Sequencing of Bacteria Isolated from the Arctic Marine Environment
2013
Adele Kim,
Bjørn,
hege lynum,
Gro Elin Kjæreng,
Marcin Miroslaw,
Nils Peder
et al.:
Discovery of Cold-active Enzymes from the Marine Arctic Environment
2013
Hege Lynum
:
Stress responses in Aliivibrio salmonicida
2010
Hege Lynum,
Laila,
Kjersti,
Aili,
Joanna,
Sean
et al.:
Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans
2010
Hege Lynum
:
Oxidative stress and iron limitation in Aliivibrio
salmonicida
Expression profiling, and molecular characterisation of
FeSOD and Fur
UiT Norges arktiske universitet 2009
Laila,
Hege Lynum,
Kjersti,
Aili,
Joanna,
S
et al.:
Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans
2009
Hege Lynum,
Ellen Kristin,
Arne O.,
Nils Peder
:
Oxidative stress in Vibrio salmonicida
2006
Inger Liv Uttakleiv,
hege lynum,
steinar,
Trond,
Nils Peder,
Arne Oskar
:
Proteomic studies of Vibrio Salmonicida
2005
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Research interests
Read more about the research projects at the home page of RAMP research group
I work as an Assoociate Professor. My research interests are in immunology and protein research. I work with the autoimmune disease Systemic Lupus Erythematosus (SLE), and my focus has been mainly related to new biomarkers and treatment of this disease.
We aim to develop new therapeutic tools and ways to monitor the disease based on novel and precise knowledge of the disease initiation and development. Since the expression of both DNase I and neutrophil extracellular traps (NETs) are abnormal in SLE, we hypothesize that they can be utilized in therapy and as biomarkers. To explore this, we will investigate the expression pattern and regulation of DNase I and NETs.
Teaching
Studieprogramleder for master i biomedisin
MBI-1105, basal biokjemi
- Forelesniger og seminarer i enzymologi
ODO-2008, 2. år odontologi
- Forelesninger, seminarer og case i immunologi
MBI-3911, masteroppgave i biomedisin
- Emneansvarlig
MED-1501, 1. år medisin
- Forelesninger, seminarer og case i immunologi
