1. Unit startpage
  2. Employees
  3. Viola Nähse
Bilde av Nähse, Viola
Bilde av Nähse, Viola
Autophagy Research Group viola.naehse@uit.no Tromsø You can find me here

Viola Nähse

  • Viola Nahse-Kumpf, Harald Alfred Stenmark, Kay Oliver Schink :
    Omegasomes control formation, expansion, and closure of autophagosomes
    Bioessays 2024 ARKIV / DOI
  • Viola Nahse-Kumpf, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Wenzel et al.:
    ATPase activity of DFCP1 controls selective autophagy
    Nature Communications 2023 ARKIV / DOI
  • Viola Nahse-Kumpf, Kay Oliver Schink, Harald Alfred Stenmark :
    ATPase-regulated autophagosome biogenesis
    Autophagy 2023 ARKIV / DOI
  • Kia Wee Tan, Viola Nahse-Kumpf, Coen Campsteijn, Andreas Brech, Kay Oliver Schink, Harald Stenmark :
    JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes
    Journal of Cell Science 2021 ARKIV / DOI
  • Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Maha Said, Viviana Barra, Viola Nahse-Kumpf et al.:
    FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
    Communications Biology 2021 DOI
  • Olivier Brison, Sami El-Hilali, Dana Azar, Stephane Koundrioukoff, Mélanie Schmidt, Viola Nahse-Kumpf et al.:
    Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
    Nature Communications 2019 DOI
  • Marion Blin, Benoît Le Tallec, Viola Nahse-Kumpf, Mélanie Schmidt, Caroline Brossas, Gael A Millot et al.:
    Transcription-dependent regulation of replication dynamics modulates genome stability
    Nature Structural & Molecular Biology 2018 DOI
  • Eva Wenzel, Sebastian Schultz, Kay Oliver Schink, Nina Marie Pedersen, Viola Nahse-Kumpf, Andreas Carlson et al.:
    Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
    Nature Communications 2018 ARKIV / DOI
  • Maja Radulovic, Kay Oliver Schink, Eva Wenzel, Viola Nahse-Kumpf, Antonino Bongiovanni, Frank Lafont et al.:
    ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
    EMBO Journal 2018 ARKIV / DOI
  • Viola Nahse, Liliane Florence Christ, Harald Alfred Stenmark, Coen Campsteijn :
    The Abscission Checkpoint: Making It to the Final Cut
    Trends in Cell Biology 2017 DOI
  • Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Øvstebø Engesæter, Viola Nahse-Kumpf, Roar Fjær et al.:
    Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma
    BMC Cancer 2015 DOI
  • Christin Lund-Andersen, Sebastian Patzke, Viola Nahse-Kumpf, Randi G. Syljuåsen :
    PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
    Radiotherapy and Oncology 2014 DOI
  • Grete Hasvold, Viola Nahse-Kumpf, Kinga Magda Tkacz-Stachowska, Einar K Rofstad, Randi G. Syljuåsen :
    The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation
    Molecular Cancer Therapeutics 2013 DOI
  • Halfdan Beck, Viola Nahse-Kumpf, Marie Sofie Yoo Larsen, Karen A. O'Hanlon, Sebastian Patzke, Christian Holmberg et al.:
    Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption
    Molecular and Cellular Biology 2012 DOI
  • Tobias Menzel, Viola Nähse, Arne Nedergaard Kousholt, Ditte Kjærsgaard Klein, Christin Lund-Andersen, Michael Lees et al.:
    A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
    EMBO Reports 2011 DOI
  • Halfdan Beck, Viola Nähse, Marie Sofie Yoo Larsen, Petra Groth, Trevor Clancy, Michael Lees et al.:
    Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
    Journal of Cell Biology 2010 DOI
  • Viola Nahse-Kumpf, Tobias Menzel, Michael Lees, C. Ahler, Christin Lund-Andersen, Claus Storgaard Sørensen et al.:
    Identification of unknown regulators of radiation-induced checkpoints by siRNA-based large scale screening
    European Journal of Cancer 2010

    • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Research interests

    My research focuses on the molecular mechanisms of autophagy, with a particular emphasis on the biogenesis and regulation of omegasomes—ER-derived membranes that initiate selective autophagy. I am particularly interested in how membrane remodeling events control autophagosome formation, expansion, and closure. We are also exploring how autophagy interfaces with ER dynamics, membrane shaping, and intracellular signaling, contributing to broader questions of organelle communication and stress adaptation.

    A key goal of my work is to understand how selective autophagy contributes to cancer progression and therapy resistance. My group investigates how autophagy supports cancer cell survival during stress, particularly in the context of radiotherapy, and aims to identify molecular targets to sensitize cancer cells to treatment. We combine mechanistic cell biology with imaging, biochemistry, and genetic perturbation tools to dissect the spatial and temporal regulation of autophagy in cancer cells.

    ORCID: https://orcid.org/0000-0002-5479-2483

    CV

    Current Positions

    2025–present: Associate Professor, Department of Medical Biology, UiT – The Arctic University of Norway, Tromsø, Norway
    2025–present: Senior Scientist, Anne Simonsen lab, Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Norway

    Previous Positions

    2023–2025: Scientist, Harald Stenmark lab, Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Norway
    2021–2023: Scientist, Elina Ikonen lab, Department of Anatomy, Faculty of Medicine, University of Helsinki, Finland
    2016–2020: Postdoc, Harald Stenmark lab, Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Norway
    2014–2016: Postdoc, Michelle Debatisse lab, CNRS UMR 3244, Institut Curie, Centre de Recherche, Paris, France

    Education

    2008–2013: PhD, Randi Syljuåsen lab, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Norway
    2002–2007: Master, Christian Schmidt lab, Department of Hematology and Oncology, University of Greifswald, Germany

    Fellowships and Grants

    2024: Helse Sør-Øst Research Grant (9 million NOK)
    2020: FRIPRO Mobility Grant, Research Council of Norway (4 million NOK)

    Prizes and Awards

    2024: Outstanding Article Award, Oslo University Hospital, Oslo, Norway
    2023: CanCell Excellence Article Award, Centre for Cancer Cell Reprogramming, University of Oslo, Norway
    2018: Native Scientist Award for outreach work, Native Scientists AS

    Outreach and Engagement

    2025–present: Volunteering at Vardesenteret, a meeting place for cancer patients, Cancer Society, University Hospital of North Norway, Tromsø, Norway
    2023–2025: Volunteering at Vardesenteret, Cancer Society, Radium Hospital, Oslo University Hospital
    2023–2025: Board Member, Norwegian Biosciences Society (NBS) Oslo; organizer of scientific meetings in Oslo, Norway
    2017–2018: Project Coordinator in Norway for Native Scientists; outreach projects for school children
     

    MH øst Kontor


    Click for bigger map